Pat Domaratz pointed me to this Geneva, NY, landmark. A quick search turned up this lovely little site on RootsWeb, which tells us:
"In 1847, John Williams Smith and S. S. Cobb opened a dry goods store
in Geneva NY under the name of Cobb & Smith. In 1849, Mr. Cobb
withdrew from the business and John Smith was joined with his brother,
Solomon E. Smith, in the operation of J. W. Smith & Co. This
store continued in operation til the mid-1900's." The site has a nice illustration of the store, too.

Among the store's employees was Samuel D. Pierson of Pittsford, whose biography is available online. If you're willing to drive a bit to do your research, Hobart & William Smith College in Geneva has a five-page history of the store among the papers of George Maxwell Blackstock Hawley, who graduated from Hobart in 1892.